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Amorphous Solid Dispersion -- An Ideal Formulation Approach to Improve Developability of Poorly Soluble Molecules, Upcoming Webinar Hosted by Xtalks

Amorphous Solid Dispersion -- An Ideal Formulation Approach to Improve Developability of Poorly Soluble Molecules, Upcoming Webinar Hosted by Xtalks

In this free webinar, learn how amorphous solid dispersion revolutionizes drug solubility, addressing aqueous solubility challenges for enhanced bioavailability and pharmaceutical development. Attendees will understand how amorphous solid dispersion differs from traditional methods, enhancing bioavailability across various drugs. Attendees will explore how amorphous solid dispersion improves drug solubility upon dissolution, boosting dissolution rates. The featured speaker will discuss amorphous solid dispersion applications for poorly soluble drugs, supported by case studies and comprehensive solutions from screening to GMP supplies.

TORONTO, Jan. 4, 2024 Discover an informative webinar uncovering the transformative impact of amorphous solid dispersion on drug solubility. Aqueous solubility results in low bioavailability and developability issues. Various approaches such as salt formation, solubilization using a co-solvent, complexation with cyclodextrin and particle size reduction have limitations for their wide applicability for all molecules.

Amorphous solid dispersion is one of the most promising approaches that not only helps overcome the limitations of these other approaches but also helps enhance the bioavailability and enable compounds to toxicity studies. The solid dispersion approach has unique advantages in terms of its applicability for a wide range of molecules, safety of vehicles and scalability.

The solid dispersion approach has unique advantages in terms of its applicability for a wide range of molecules, safety of vehicles and scalability.

Solid dispersion refers to the dispersion of one or more active ingredients in a hydrophilic inert carrier matrix at the molecular level. It is prepared by the melt (fusion) method or the solvent evaporation technique. The basic principle of this technique involves the conversion of crystalline drug substance to an amorphous form and stabilised in a hydrophilic polymer.

When the solid dispersion comes in contact with the aqueous medium, the inert carrier dissolves releasing the drug and the increased surface area produces a higher apparent solubility and dissolution rate, thereby increasing the bioavailability of the poorly soluble drug substance.

In this webinar, Sreehari Babu, Sr. Vice President — Formulations Solutions at Aragen Life Sciences, will deep dive into how amorphous solid dispersion is an ideal approach for poorly soluble drug substances and demonstrate how Aragen can offer end-to-end solutions from screening to good manufacturing practice (GMP) supplies through technology overview and case studies.

Join this webinar to learn how amorphous solid dispersion revolutionizes drug solubility, addressing aqueous solubility challenges for enhanced bioavailability and pharmaceutical development.

Join Sreehari Babu Putchakayala, SVP & Head, Formulation Development Solutions, Aragen, for the live webinar on Wednesday, January 24, 2024, at 11am EST (4pm GMT/UK).

For more information, or to register for this event, visit Amorphous Solid Dispersion — An Ideal Formulation Approach to Improve Developability of Poorly Soluble Molecules.

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